Debugger not hitting any breakpoints on new 8.1 boxes

I have had a few 8.1 dev boxes where the debugger just wouldn't hit any breakpoints.

The cause is this related to this setting in Visual Studio:

On the new boxes where I have had the problem "Only specified modules" was active, but no modules were specified. You can change this to "All modules, unless excluded" or figure out precisely which modules add.
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