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Help: SQL Server goes crazy!

You might have noticed it. But the last 2 hours something has been wrong here! The website has slowed down! Not a little but a lot!

On the server I can see that my SQL Server (sqlserv.exe) suddenly is using almost 100% of my CPU.

What can I do to check exactly what's wrong? I've tried to reboot a few times but it's just the same when it comes back again.

The activity monitor with SQL doesn't give me much information.